Clinical Trial: Hypovitaminosis D and an Inadequate PTH Response in Chronic Liver Disease Patients

Study Status: Terminated
Recruit Status: Terminated
Study Type: Interventional

Official Title: Hypovitaminosis D and an Inadequate PTH Response in Chronic Liver Disease Patients

Brief Summary: The purpose of this study is to determine how common low levels of magnesium are in patients with end stage liver disease. In addition, investigator is trying to determine if low levels of magnesium affect the release of parathyroid hormone in patients with end stage liver disease and low vitamin D levels

Detailed Summary: Hypovitaminosis D is a common condition found in patients referred for orthotopic liver transplant. The classical physiologic response to vitamin D deficiency is the development of secondary hyperparathyroidism. However, several previous studies have found a high incidence of inappropriate functional hypoparathyroidism in patients with chronic liver disease and hypovitaminosis D. The mechanism underlying this functional hypoparathyroidism is not understood but previous investigators have postulated that it is related to intracellular magnesium (Mg) deficiency. Our short term goals of this pilot project are two fold: (a) We will estimate the prevalence of magnesium deficiency in chronic liver disease patients by performing standard Mg loading testing (b) We will examine the effects of acute intravenous Mg infusion on the calcium-PTH axis. The vitamin D-PTH endocrine system is one of the principal regulators of calcium homeostasis and bone metabolism. Metabolic bone disease is a quite pervasive problem in chronic liver disease patients. Insight into this important endocrine system will aid us in our long term goals of addressing metabolic bone disease issues in this patient population.
Sponsor: Rajib Bhattacharya, MD

Current Primary Outcome: Perform a standard magnesium loading test to determine urinary magnesium retention in order to define prevalence of magnesium insufficiency in a chronic liver disease population [ Time Frame: One Month ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Evaluate the effects of intravenous magnesium loading on the calcium-PTH endocrine axis by measuring pre and immediate post infusion calcium and PTH [ Time Frame: One Month ]

Original Secondary Outcome: Same as current

Information By: University of Kansas Medical Center

Dates:
Date Received: January 11, 2008
Date Started: January 2008
Date Completion:
Last Updated: May 28, 2013
Last Verified: May 2013