Clinical Trial: Estradiol and Testosterone Levels in Seminal Plasma of Men With Non-obstructive Azoospermia
Study Status: Completed
Recruit Status: Completed
Study Type: Observational
Official Title: Are Estradiol and Testosterone Levels in Seminal Plasma Predictive for Efficient Spermatogenesis in Men With Non- Obstructive Azoospermia
Brief Summary: Estradiol and Testosterone are two important hormones for the regulation of an effective spermatogenesis in human testis. The evaluation of levels of estradiol and testosterone in seminal plasma of men with non-obstructive azoospermia may be a predictive test before surgical testicular biopsy to determine the chance of a positive sperm extraction to use for ICSI.
Detailed Summary: The aim of this study is to compare the levels of esttradiol and testosterone in seminal plasma of men with non-obstructive azoospermia. Indeed, for these patients, none biological test allows to predict a positive sperm extraction before the surgical testis biopsy is performed. Since the involvement of estradiol and testosterone in the regulation of spermatogenesis, the measurement of these hormones in seminal plasma may be a predictive tool for these men before testis biopsy.
Sponsor: University Hospital, Clermont-Ferrand
Current Primary Outcome:
- Levels of estradiol and testosterone in seminal plasma of men with non-obstuctive azoospermia [ Time Frame: at 1 month ]
- Issue of testicular biopsy (sperm extraction positive or negative) [ Time Frame: at day 1 ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- Degrees of alteration of testis histology [ Time Frame: at day 1 ]
- Serum levels of estradiol and testosterone [ Time Frame: at day 1 ]
Original Secondary Outcome: Same as current
Information By: University Hospital, Clermont-Ferrand
Dates:
Date Received: September 26, 2014
Date Started: January 2009
Date Completion:
Last Updated: September 30, 2014
Last Verified: September 2014
