Clinical Trial: Serum Magnesium and Vascular Calcification
Study Status: Completed
Recruit Status: Completed
Study Type: Observational
Official Title: Comparison of Vascular Calcification Between Kidney Transplant Recipients and Predialysis Chronic Kidney Disease and Its Association With Serum Magnesium
Brief Summary: Both Kidney transplantation (KT) and Chronic Kidney Disease (CKD) patients have reduced kidney function. Low serum magnesium is more prevalent in KT recipients. The present study examines the difference in vascular calcification between KT and CKD and its association with serum magnesium.
Detailed Summary: Kidney transplantation (KT) improved quality of life and longevity of CKD patients. Nevertheless, kidney function deteriorates overtime in a manner not different from CKD counterparts. Hypomagnesemia is prevalent in KT recipients secondary to immunosuppressive therapy. In addition to serum calcium, phosphate and elemental calcium intake, the relationship between low serum magnesium and vascular calcification (VC) has been observed in small studies in CKD. Whether low serum magnesium associates with VC in KT has never been elucidated. The present study compares vascular calcification between KT and CKD and its association with serum magnesium.
Sponsor: Ramathibodi Hospital
Current Primary Outcome: The difference in vascular calcification score between KT and CKD [ Time Frame: Baseline ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- The association of serum magnesium with vascular calcification in KT [ Time Frame: Baseline ]
- The association of serum magnesium with vascular calcification in CKD [ Time Frame: Baseline ]
Original Secondary Outcome: Same as current
Information By: Ramathibodi Hospital
Dates:
Date Received: February 10, 2011
Date Started: February 2011
Date Completion:
Last Updated: May 25, 2011
Last Verified: May 2011
