Clinical Trial: Platelet Transfusion in Acute Intracerebral Hemorrhage
Study Status: Completed
Recruit Status: Unknown status
Study Type: Interventional
Official Title: Platelet Transfusion in Acute Primary Intracerebral Hemorrhage for Patients on Platelet Inhibitors
Brief Summary:
- To prove whether use of antiplatelet agents results into a rapid enlargement of hematoma after onset of acute intracerebral hemorrhage.
- To prove the efficacy and safety of platelet transfusion for prevention of hematoma growth in patients who were stricken by acute intracerebral hemorrhage while being on antiplatelet medication.
Detailed Summary:
- Hematoma growth is a well-known powerful determinant of mortality and poor outcome after intracerebral hemorrhage.
- Some observations suggest that previous use of antiplatelet agents associates with rapid hematoma enlargement and poor outcome after cerebral hemorrhage.
- Immediate platelet transfusion for such patients may prevent hematoma growth but also cause thromboembolic complications.
Sponsor: University of Oulu
Current Primary Outcome: Hematoma growth within 24 h measured as increase in hematoma volume observed by head CT [ Time Frame: 24 hours ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- Glasgow Outcome Score [ Time Frame: 90 days ]
- Cardiovascular death occurring within the treatment period [ Time Frame: 90 days ]
- Death due to any cause occurring within the treatment period [ Time Frame: 90 days ]
- Acute myocardial infarction [ Time Frame: 90 days ]
- Venous thromboembolism [ Time Frame: 90 days ]
Original Secondary Outcome: Same as current
Information By: University of Oulu
Dates:
Date Received: June 12, 2008
Date Started: January 2009
Date Completion: December 2014
Last Updated: July 1, 2010
Last Verified: July 2010
