Clinical Trial: Myocardial Stress Perfusion Computed Tomography in the Evaluation of Patients With Acute Chest Pain Using a Novel 3rd Generation Dual-source CT System

Study Status: Suspended
Recruit Status: Suspended
Study Type: Interventional

Official Title: Myocardial Stress Perfusion Computed Tomography in the Evaluation of Patients With Acute Chest Pain Using a Novel 3rd Generation Dual-source CT System

Brief Summary: To assess the ability of a novel 3rd generation dual-source CT system to demonstrate myocardial perfusion in a cohort of patients presenting to the Chest Pain Center with acute chest pain.

Detailed Summary: The investigators will assess the latest generation of CT scanner for heart disease detection. On this new machine the investigators will analyse the ability of the machine to show the delivery of blood to the heart muscle. Results will be compared with the results from the gold standard test for myocardial perfusion imaging, which is an imaging test that shows the blood supply to the heart muscle. Further analyses will record the amount of radiation, which is how the CT machine acquires images, and compare the amount of radiation necessary to produce images to previous CT systems. With this new CT system there should be reductions in the amount of radiation dose compared to previous systems.
Sponsor: Medical University of South Carolina

Current Primary Outcome: Diagnostic Accuracy of Dynamic Perfusion CT [ Time Frame: 1 Day ]

Diagnostic accuracy of dynamic perfusion CT of the heart for evaluation of perfusion, viability and function during stress and rest compared with SPECT myocardial perfusion imaging.


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • CTMP/SPECT MPI Disagreement [ Time Frame: 1 Day ]
    Evaluate the accuracy of CT myocardial perfusion and SPECT using a stress/rest and delayed enhancement MRI examination as gold-standard.
  • Radiation Dose [ Time Frame: 1 Day ]
    Assess the radiation dose delivered with the myocardial perfusion CT comparing the results with those obtained at SPECT.


Original Secondary Outcome: Same as current

Information By: Medical University of South Carolina

Dates:
Date Received: November 21, 2014
Date Started: December 2014
Date Completion:
Last Updated: March 23, 2017
Last Verified: March 2017