Clinical Trial: Ultrasound Therapy In Cardiac Amyloidosis

Study Status: RECRUITING
Recruit Status: RECRUITING
Study Type: INTERVENTIONAL

Official Title: Ultrasound Therapy In Cardiac Amyloidosis

Brief Summary: This is a prospective pilot clinical study of subjects with cardiac amyloidosis and control subjects without amyloidosis where we plan to evaluate changes in myocardial blood flow, systolic and diastolic function before and after sonotherapy.

Detailed Summary: 70 subjects will be enrolled in this study in 3 study groups: A) 30 subjects with light chain cardiac amyloidosis B) 30 subjects with transthyretin cardiac amyloidosis and C) 10 subjects without amyloidosis.
All subjects will undergo rest 2D echocardiography, rest N-13 ammonia or rubidium-82 perfusion PET, Definity infusion with high mechanical index (MI) imaging defined as sonotherapy in this study protocol.
Sponsor: Brigham and Women's Hospital

Current Primary Outcome: N-13 ammonia or Rubidium-82 PET based measure of myocardial blood flow in ml/gm/min

Original Primary Outcome: N-13 ammonia or Rubidium-82 PET based measure of myocardial blood flow in ml/gm/min

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Brigham and Women's Hospital

Dates:
Date Received: December 03, 2020
Date Started: August 31, 2023
Date Completion: August 31, 2023
Last Updated: December 01, 2023
Last Verified: December 01, 2023