Clinical Trial: Aerosol Inhalation Treatment for Dyspnea
Study Status: Active, not recruiting
Recruit Status: Active, not recruiting
Study Type: Interventional
Official Title: Aerosol Inhalation Treatment for Dyspnea
Brief Summary: The purpose of this protocol is to develop and test optimal delivery of aerosol furosemide, a treatment that has the potential to significantly improve symptom management and enhance the quality of care for patients with intractable dyspnea.
Detailed Summary: This is study of aerosol treatment in a laboratory model of dyspnea in healthy subjects. This study is the first in a series of studies that will include investigation of a second dose in the laboratory and investigation of the treatment effect in hospitalized patients with refractory dyspnea. The outcome of this first study will determine the details of protocol for the succeeding studies.
Sponsor: Beth Israel Deaconess Medical Center
Current Primary Outcome: Subject rating of Breathing Discomfort (dyspnea) [ Time Frame: repeated measurement for 2 hours from intervention ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- Multidimensional Dyspnea Profile [ Time Frame: repeated for 2 hours after intervention ]
- Urine output [ Time Frame: repeated measures for 2 hours after intervention ]diuresis is an expected effect of furosemide. to the extent that aerosol furosemide is absorbed into the blood, diuresis is an expected 'side effect' of this treatment
Original Secondary Outcome: Same as current
Information By: Beth Israel Deaconess Medical Center
Dates:
Date Received: September 23, 2011
Date Started: September 2011
Date Completion: August 2017
Last Updated: March 6, 2017
Last Verified: March 2017