Clinical Trial: Erythrocyte and Adipocyte G6PD Activity Levels in Obesity

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Erythrocyte and Adipocyte G6PD Activity Levels Correlate With Differing Degrees of Dyslipidemia, Insulin Resistance and Obesity

Brief Summary: This study compares the improvement of weight, fasting lipid profile (triglycerides, cholesterol, HDL, and LDL) and diabetes after gastric bypass surgery with an improvement in levels of an enzyme called glucose-6-phosphate dehydrogenase (G6PD).

Detailed Summary: Same as brief summary
Sponsor: University of South Alabama

Current Primary Outcome: Measure erythrocyte G6PD levels in diabetic vs. non-diabetic morbidly obese patients undergoing laparoscopic Gastric Bypass. [ Time Frame: time of surgery up to 24 months post gastric bypass ]

G6PD levels will be measured at the following time intervals: Baseline(prior to gastric bypass surgery), 1 week, 6 weeks, 12 weeks, 6 months, 12 months and 24 months post surgery.


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Measure adipocyte G6PD levels in diabetic vs. non-diabetic morbidly obese patients undergoing laparoscopic gastric bypass. [ Time Frame: time of surgery up to 12 weeks post gastric bypass ]
  • Measure omentum G6PD levels in diabetic vs. non-diabetic morbidly obese patients undergoing laparoscopic gastric bypass. [ Time Frame: time of surgery up to 12 weeks post gastric bypass ]
  • Measure hepatocyte G6PD levels in diabetic vs. non-diabetic morbidly obese patients undergoing laparoscopic gastric bypass. [ Time Frame: time of surgery up to 12 weeks post gastric bypass ]


Original Secondary Outcome: Same as current

Information By: University of South Alabama

Dates:
Date Received: June 23, 2010
Date Started: December 2009
Date Completion:
Last Updated: February 1, 2016
Last Verified: January 2013