Clinical Trial: Role of Antibiotics to Reduce Infectious Complications in Tube Thoracotomy Management of Traumatic Hemopneumothorax

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: The Role of Antibiotics in the Reduction of Infectious Complications in Tube Thoracotomy Management of Traumatic Hemopneumothorax: A Prospective, Double-Blinded Study

Brief Summary: The purpose of this study is to examine the efficacy of prophylactic antibiotics in patients with chest tubes for management of thoracic injuries in the reduction of the incidence of empyema as compared to placebo.

Detailed Summary: In this study, the medication (an antibiotic which is used to treat or prevent infections) will be compared with a placebo. A placebo is something that looks like a "real" medication, but it doesn't contain any active medication. As a participant in this study, you may receive the active medication (Cefazolin Sodium Injection or Clindamycin) or you may receive a placebo.
Sponsor: St. Luke's Hospital, Pennsylvania

Current Primary Outcome: efficacy of prophylactic antibiotics in reduction of empyema [ Time Frame: 30 days ]

The primary objective of this study is to examine the efficacy of prophylactic antibiotics in patients with chest tubes for management of thoracic injuries in the reduction of the incidence of empyema as compared to placebo.


Original Primary Outcome: Same as current

Current Secondary Outcome: Incidence of Pneumonia and/or development of resistant microorganisms [ Time Frame: 30 days ]

Secondary objectives include:

Incidence of pneumonia Incidence of development of resistant microorganisms



Original Secondary Outcome: Same as current

Information By: St. Luke's Hospital, Pennsylvania

Dates:
Date Received: May 19, 2010
Date Started: July 2005
Date Completion:
Last Updated: May 20, 2010
Last Verified: February 2009