Clinical Trial: PEG (Polyethylene Glycol)Versus Lactulose For Treatment Of Overt Hepatic Encephalopathy

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Randomized Trial Comparing The Efficacy of PEG (Polyethylene Glycol) Versus Lactulose For Treatment Of Overt Hepatic Encephalopathy

Brief Summary: The current standard of care for patients with HE includes non-absorbable disaccharides(lactulose);The chemical name for lactulose is 4-O-β-D-galactopyranosyl-D-fructofuranose.The exact mode of action by lactulose is thought to be the conversion to lactic acid and acetic acid by colonic bacteria resulting in acidification of the gut lumen. This favors conversion of ammonia (NH3) to ammonium (NH4+), which is relatively membrane impermeable; therefore, less ammonia is absorbed by the colon. Gut acidification inhibits ammoniagenic coliform bacteria, leading to increased levels of nonammoniagenic lactobacilli. Nonabsorbable disaccharides also work as a cathartic, clearing the gut of ammonia before it can be absorbed.

Detailed Summary: Polyethylene glycol electrolyte solution (PEG) is a laxative solution that increases the amount of water in the intestinal tract to stimulate bowel movements. It is used safely to clean the bowel before colonoscopy.
Sponsor: Sherief Abd-Elsalam

Current Primary Outcome: 1 or more in HE grade improvement at 24 hours [ Time Frame: 24 hours ]

HE grade improvement at 24 hours


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Time to HE resolution [ Time Frame: 2 weeks ]
    Time to Hepatic encephalopathy resolution
  • Overall length of stay [ Time Frame: 2 weeks ]
    Overall length of stay


Original Secondary Outcome: Same as current

Information By: Tanta University

Dates:
Date Received: March 24, 2017
Date Started: March 11, 2017
Date Completion: December 2019
Last Updated: April 25, 2017
Last Verified: April 2017