Clinical Trial: A Small Clinical Study: Photodynamic Therapy to Treat Hidradenitis Suppurativa
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: A Small Clinical Study: Photodynamic Therapy to Treat Hidradenitis Suppurativa
Brief Summary: This study will investigate the efficacy of Photodynamic Therapy (PDT), which is the therapeutic use of photochemical reactions, in treating hidradenitis suppurativa (HS), a chronic inflammatory condition affecting areas of skin with sweat glands. We expect that PDT is effective in treating HS.
Detailed Summary:
This study will investigate the efficacy of PDT using aminolevulinic acid (ALA) and either blue light or intense pulsed light on active lesions of HS. We will attempt to validate the success noted in a previously published case series using PDT with ALA and blue light (Gold, Bridges et al). We will evaluate effect of treatment by number of lesions, global disease severity, and patient self-assessment with the Dermatology Life Quality Index (DLQI).
Detailed informed consent will be obtained prior to treatment at study enrollment. The first four treatment visits will involve clinical evaluation, photography and application of the ALA to the affected area. After a 45 minute incubation period, the area will be washed and then treated with either blue light or intense pulsed light (IPL), depending on body area/investigator choice. One and three-month follow-up visits will involve evaluation of efficacy, but no active treatment.
Gold M, Bridges TM, et al. ALA-PDT and blue light therapy for hidradenitis suppurative. J Drugs Dermatol. 2004; 3 (1 Suppl):S32-5.
Sponsor: University of Kansas
Current Primary Outcome: Active and inactive lesion count [ Time Frame: 0,1,2,3,4,8,16 weeks ]
Original Primary Outcome: Active and inactive lesion count
Current Secondary Outcome: Regional disease severity will be assessed at each visit. Global Severity Score will be assigned by investigator. Assessed at all 6 visits, Patient self -assessment (DLQI) at visits 4-6,-Digital photographs-all 6 visits,Safety/adverse event monitoring. [ Time Frame: 0,1,2,3,4,8,16 weeks ]
Original Secondary Outcome: Regional disease severity will be assessed at each visit. Global Severity Score will be assigned by investigator. Assessed at all 6 visits, Patient self -assessment (DLQI) at visits 4-6,-Digital photographs-all 6 visits,Safety/adverse event monitoring.
Information By: University of Kansas Medical Center
Dates:
Date Received: November 1, 2006
Date Started: October 2006
Date Completion:
Last Updated: October 4, 2007
Last Verified: October 2007
