Clinical Trial: Efficacy & Safety of Clindamycin and Tretinoin in Acne

Study Status: Completed
Recruit Status: Unknown status
Study Type: Interventional

Official Title: Efficacy & Safety of Clindamycin Phosphase 1.2% and Tretinoin 0.025% Gel vs. Vehicle for the Treatment of Acne and Acne-Induced Post Inflammatory Hyperpigmentation in

Brief Summary:

The purpose of this study is ascertain the efficacy and safety of Clindamycin

Phosphate 1.2% and Tretinoin 0.025% in the treatment of Acne and Post

Inflammatory Hyperpigmentation in patients with skin of color.

Detailed Summary:

Acne is a chronic disorder of the pilosebaceous glands characterized by

inflammatory papules, pustules, opened and closed comedones, cysts and

nodules. Post inflammatory hyperpigmentation is a condition in which an

inflammation from a disease such as acne, trauma, or abrasion results in areas

of the skin with increased melanin content compared to the surrounding skin.

There are several treatments available for acne, which include benzoyl

peroxide,antibiotics (topical or oral), and topical retinoids (tretinoin,

tazarotene, adapalene). Combination therapy, such as topical retinoid and

clindamycin, has been shown to be more effective than monotherapy in

addressing all pathogenic factors of acne.

Sponsor: Callender Center for Clinical Research

Current Primary Outcome: Improvement of acne and post inflammatory hyperpigmentation [ Time Frame: 3 months ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Callender Center for Clinical Research

Dates:
Date Received: April 26, 2010
Date Started: November 2009
Date Completion: April 2010
Last Updated: May 19, 2010
Last Verified: May 2010