Clinical Trial: The Efficacy of Isocapnic Hyperpnoea to Accelerate Recovery After General Anesthesia With Sevoflurane

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: The Efficacy of Isocapnic Hyperpnoea to Accelerate Recovery After General Anesthesia With Sevoflurane.

Brief Summary: The twilight phase between being asleep and awake during recovery from anesthesia is a precarious time fraught with risks to the post-operative patient. Hyperventilation accelerates the elimination of inhaled anesthetics but reduces their CO2 blood concentrations which delays their resumption of spontaneous breathing. We previously showed that our method of hyperventilation without affecting the CO2 concentration--which we call IH--accelerates the rate of emergence from anesthesia with isoflurane. In this study we will study the effect of IH on the rate of emergence from Sevoflurane anesthesia.

Detailed Summary:
Sponsor: University Health Network, Toronto

Current Primary Outcome: Time to recovery from anesthesia as indicated by time to extubation and rate of change of BIS score

Original Primary Outcome: Same as current

Current Secondary Outcome: Quality of recovery in the recovery room as indicated by the level of consciousness, incidence of nausea, vomiting, shivering and other phenomena occuring during recovery

Original Secondary Outcome: Same as current

Information By: University Health Network, Toronto

Dates:
Date Received: October 18, 2005
Date Started: October 2005
Date Completion:
Last Updated: August 3, 2010
Last Verified: September 2006