Clinical Trial: The Role of MMPs in the CXCL12-Induced Invasion of Laryngeal and Hypopharyngeal Squamous Cell Carcinoma

Study Status: Recruiting
Recruit Status: Unknown status
Study Type: Observational

Official Title:

Brief Summary: Investigate the role of MMPs in the CXCL12-induced invasion of laryngeal and hypopharyngeal squamous cell carcinoma

Detailed Summary:

Cancer of the larynx and hypopharynx remains the third most common head and neck malignancy, constituting about 20% of all tumors. Squamous cell carcinoma (SCC) is the most common histopathologic type of the laryngeal and hypopharyngeal malignancies, accounting for more than 90% of cancers occurring in this region (1). Lymph node metastasis directly affects the prognosis of patients with laryngeal and hypopharyngeal SCC (2). The presence of lymph node metastasis significantly reduces the probability of regional control and survival (3). Furthermore, the American Cancer Society shows no trend toward an improvement in 5-year survival rates between patients diagnosed in 1974 to 1976 and 1989 to 1995 (4).

Tumor metastasis is the hallmark of malignancy, and is probably a result of the interaction between tumor cells and a supportive microenvironment. Malignant cells that have the capability to metastasize to a particular organ may have various properties supporting their tissue invasion or growth such as enhanced adherence to the microvascular cells of the organ, higher responsiveness to chemotactic signals released from the target organs and increased response to local soluble or tissue associated growth signals in the target organ (5,6). Though there are several molecules expressed or produced in cancer cells are considered the metastatic factors, it remains unknown which factors produced by the lymph node or tissue affect the metastasis of cancer cells.

Chemokines are a large family of pro-inflammatory polypeptide cytokines, consisting of small (7–15 kDa), structurally related heparin-binding proteins. They are grouped into CXC chemokines and CC chemokines, on the basis of the characteristic presence of four conserved cysteine residues (7-9). Chemokines are produced locally in the tissues and act on target cells throug
Sponsor: National Taiwan University Hospital

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Information By: National Taiwan University Hospital

Dates:
Date Received: March 12, 2006
Date Started: August 2006
Date Completion: July 2007
Last Updated: March 12, 2006
Last Verified: December 2005