Clinical Trial: Does Topical Steroid Treatment Impair the Adrenal Function?

Study Status: Completed
Recruit Status: Unknown status
Study Type: Observational

Official Title: Low Dose (1mcg) ACTH Stimulation Test for Assessment of the Hypothalamo-Pituitary- Adrenal Axis in Patients Treated With Topical Corticosteroids

Brief Summary: The purpose of this study is to determine if topical steroids treatment for different skin diseases suppress the adrenal cortisol production.

Detailed Summary:

Adrenocortical suppression is a potential complication of systemic corticosteroid treatement but also of non systemic therapy like topical therapy.

The normalcy of hypothalamic-pituitary-adrenal axis ( HPA axis) of patients with chronic skin diseases like atopic dermatitis, pemphigus or psoriasis which are treated with topical steroids, will be assessed with the low dose (1mcg) adrenocortocotropin ( ACTH) stimulation test. During this test serum cortisol levels are measured before, 30 and 60 mn after intravenous administration of 1mcg of ACTH (synacthen).The results will be compared with age and sex matched subjects with normal HPA axis as assessed by low dose ACTH stimulation test.

Sponsor: HaEmek Medical Center, Israel

Current Primary Outcome:

Original Primary Outcome:

Current Secondary Outcome:

Original Secondary Outcome:

Information By: HaEmek Medical Center, Israel

Dates:
Date Received: May 21, 2007
Date Started: May 2007
Date Completion:
Last Updated: May 21, 2007
Last Verified: May 2007