Clinical Trial: Clinical Significance of Intra-abdominal Hypertension in Surgical Patients With Severe Sepsis

Study Status: Completed
Recruit Status: Completed
Study Type: Observational [Patient Registry]

Official Title: Observational Study of Relationship Between Intra-abdominal Hypertension and Severe Sepsis in Surgical Patients

Brief Summary:

  • Intra-abdominal pressure(IAP) is defined as a steady state pressure of the abdominal cavity
  • many studies have proved IAP as a prognostic factor that elevated IAP influences hemodynamics and multiple organs dysfunction
  • In previous studies, most of them was based on the septic patients of medical diseases. And it is rare about sepsis of surgical diseases such as traumatized or postoperative patients
  • We hypothesized that intra-abdominal hypertension may affect clinical course such as length of stay of intensive care unit, weaning of mechanical ventilation, proceeding of enteral feeding and mortality
  • Our study was aimed to investigate prevalence of IAH and risk factors and to analyze clinical course and prognosis influenced by IAH in surgical patients with severe sepsis

Detailed Summary:

  • Inclusion criteria older than 18 diagnosed as severe sepsis agreed on informed consent
  • Exclusion criteria refused to participate in the study traumatic injuries on urethra or bladder open abdomen status
  • Definition of severe sepsis organ failure more than one organ with sepsis arterial blood lactate concentration of at least 4mmol/L hypotension with a systolic blood pressure lower than 90mmHg
  • Definition of intra-abdominal hypertension intra-abdominal pressure more than 12mmHg
  • Measurement of IAP measuring via three lument urinary catheter measuring after filling with 25ml normal saline measuring in supine position at level of mid-axillary line on iliac crest measuring three times a day during ICU stay

Sponsor: University of Ulsan

Current Primary Outcome: effects of intra-abdominal hypertension on clinical course and outcome in surgical patients with severe sepsis [ Time Frame: within 60 days after admission in surgical intensive care unit ]

length of ICU stay length of hospital stay ventilator free days effect on enteral feeding 28 day and 60 day mortality


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: University of Ulsan

Dates:
Date Received: February 3, 2013
Date Started: March 2009
Date Completion:
Last Updated: February 3, 2013
Last Verified: February 2013