Clinical Trial: Clinical Significance of Intra-abdominal Hypertension in Surgical Patients With Severe Sepsis
Study Status: Completed
Recruit Status: Completed
Study Type: Observational [Patient Registry]
Official Title: Observational Study of Relationship Between Intra-abdominal Hypertension and Severe Sepsis in Surgical Patients
Brief Summary:
- Intra-abdominal pressure(IAP) is defined as a steady state pressure of the abdominal cavity
- many studies have proved IAP as a prognostic factor that elevated IAP influences hemodynamics and multiple organs dysfunction
- In previous studies, most of them was based on the septic patients of medical diseases. And it is rare about sepsis of surgical diseases such as traumatized or postoperative patients
- We hypothesized that intra-abdominal hypertension may affect clinical course such as length of stay of intensive care unit, weaning of mechanical ventilation, proceeding of enteral feeding and mortality
- Our study was aimed to investigate prevalence of IAH and risk factors and to analyze clinical course and prognosis influenced by IAH in surgical patients with severe sepsis
Detailed Summary:
- Inclusion criteria older than 18 diagnosed as severe sepsis agreed on informed consent
- Exclusion criteria refused to participate in the study traumatic injuries on urethra or bladder open abdomen status
- Definition of severe sepsis organ failure more than one organ with sepsis arterial blood lactate concentration of at least 4mmol/L hypotension with a systolic blood pressure lower than 90mmHg
- Definition of intra-abdominal hypertension intra-abdominal pressure more than 12mmHg
- Measurement of IAP measuring via three lument urinary catheter measuring after filling with 25ml normal saline measuring in supine position at level of mid-axillary line on iliac crest measuring three times a day during ICU stay
Sponsor: University of Ulsan
Current Primary Outcome: effects of intra-abdominal hypertension on clinical course and outcome in surgical patients with severe sepsis [ Time Frame: within 60 days after admission in surgical intensive care unit ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
Original Secondary Outcome:
Information By: University of Ulsan
Dates:
Date Received: February 3, 2013
Date Started: March 2009
Date Completion:
Last Updated: February 3, 2013
Last Verified: February 2013