Clinical Trial: Characterization of Auditory Processing Involved in the Encoding of Speech Sounds

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Characterization of Ascending and Descending Auditory Processing Involved in the Encoding of Speech Sounds in Adult and Children: Variability Related to Changes in Sensory Input or a Neurodevelopmenta

Brief Summary: The ability to encode the speech signal is determined by ascending and descending auditory processing. Difficulties in processing these speech signals are well described at the behavioral level in a specific language disorder. However, little is known about the underlying pathophysiological mechanisms. The assumption is that we should observe a degradation of the signal provided by the ear in the deaf subject while in case of specific language impairment it would be a phonemic disorder (possibly linked to a processing disorder auditory). The two population groups should therefore have different abnormalities of their central auditory process - which could be modified by the target remediation for each group.

Detailed Summary:
Sponsor: Hospices Civils de Lyon

Current Primary Outcome: Change from Baseline speech auditory brainstem and late responses (composite and objective measure) in response to syllables (behavioral measure) [ Time Frame: Arms 2 and 3: Baseline and 5 weeks / Arms 5 and 6: Baseline and 6 months / Arms 1 and 4: Baseline ]

Spectro-temporal analysis of speech auditory brainstem and late responses : The speech brainstem and cortical responses are simultaneously obtained in response of different selected syllables from a continuum (selected by using a phonemic identification test) which is presented throughout a behavioral categorical procedure


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Change from Baseline medial olivocochlear system (MOCS) functioning measured using the contralateral suppressive effect of transient evoked otoacoustic emissions (composite measure) [ Time Frame: Arms 2 and 3: Baseline and 5 weeks / Arms 5 and 6: Baseline and 6 months / Arms 1 and 4: Baseline ]
    Measurement of the contralateral suppressive effect of transient evoked otoacoustic emissions (expressed as Equivalent Attenuation)
  • Change from Baseline dichotic skills measured using central auditory processing tests (composite measure) [ Time Frame: Arms 2 and 3: Baseline and 5 weeks / Arms 5 and 6: Baseline and 6 months / Arms 1 and 4: Baseline ]
    Presentation of different speech material to both ears simultaneously
  • Change from Baseline speech-noise listening skills measured using logatomes tests (composite measure) [ Time Frame: Arms 2 and 3: Baseline and 5 weeks / Arms 5 and 6: Baseline and 6 months / Arms 1 and 4: Baseline ]
    Presentation of disyllabic words in presence of increasing noise levels


Original Secondary Outcome: Same as current

Information By: Hospices Civils de Lyon

Dates:
Date Received: August 14, 2015
Date Started: October 2014
Date Completion: May 2018
Last Updated: August 26, 2016
Last Verified: August 2016