Clinical Trial: Evaluation of T1rho Magnetic Resonance Imaging for Diagnosis of Cartilage Lesions in Hips With Developmental Dysplasia

Study Status: Active, not recruiting
Recruit Status: Unknown status
Study Type: Interventional

Official Title: Evaluation of T1rho Magnetic Resonance Imaging for Diagnosis of Cartilage Lesions in Hips With Developmental Dysplasia

Brief Summary:

When arthritis starts it can be noticed first in certain molecules in your joint. Proteoglycan is a molecule that is important to cartilage structure, and is lost as arthritis develops. Magnetic resonance imaging (MRI) is one of the best ways to image cartilage, and an investigational MRI technique that has shown great promise in detecting proteoglycan amounts is called T1-rho.

In this study, patients with hip dysplasia will undergo this investigational MRI in addition to a well validated MRI method (called dGEMRIC) to see if T1-rho is as good as dGEMRIC at detecting cartilage damage. The dGEMRIC MRI requires an injection of a contrast agent, while the T1-rho MRI does not. If the T1-rho is shown to be as useful as the dGEMRIC method it can then be used to look at cartilage damage in the hip without having to have an injection.


Detailed Summary:
Sponsor: Ottawa Hospital Research Institute

Current Primary Outcome: To assess proteoglycan amounts in hip cartilage in patients diagnosed with DDH and scheduled to undergo surgery to correct this problem. [ Time Frame: Within the 6 months prior to surgery ]

Our aim is to correlate T1-rho with dGEMRIC values in painful hips with underlying DDH. To achieve this, we will assess whether T1-rho MRI values correlate with dGEMRIC MRI values in hips with DDH.


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Ottawa Hospital Research Institute

Dates:
Date Received: June 2, 2014
Date Started: July 2015
Date Completion:
Last Updated: February 8, 2015
Last Verified: February 2015