Clinical Trial: Study of Blood and Cheek Cell Samples From Patients With Glioma

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: San Francisco Bay Area Adult Glioma Prognosis Study Protocol

Brief Summary:

RATIONALE: Studying samples of blood and tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors predict how patients will respond to treatment.

PURPOSE: This research study is looking at blood and cheek cell samples from patients with glioma.


Detailed Summary:

OBJECTIVES:

Primary

  • Determine factors related to glioma survival in patients from two population-based case series collected in the San Francisco Bay Area between August 1991 and April 1994 (series 1) and May 1997 and August 1999 (series 2).

Secondary

  • Determine vital status for 879 patients in the two San Francisco Bay Area population-based series through July 2004.
  • Determine survival as a function of established, potential, and yet unstudied prognostic indicators.
  • Gather data to validate results from this study with information from adult glioma patients enrolled prospectively at the UCSF-Neuro-Oncology clinic and through series 3 of the San Francisco Bay Area Adult Glioma Study; incorporate results from this study and other components of the SPORE into ongoing clinical investigations at the Brain Tumor Research Center and Neuro-Oncology Service at UCSF.
  • Using funding from the organization Accelerate Brain Cancer Cure (ABC2), genotype several thousand single nucleotide polymorphisms (SNPs) from some study participants; assess these SNPs for potential relationship to glioma survival.

OUTLINE: Medical records of patients registered to the California Cancer Registry or the Northern California Cancer Center SEER are reviewed for mortality and treatment information related to the brain tumor. Blood and buccal specimens are collected from patients with newly diagnosed disease who are being seen at the UCSF Neuro-Oncology Service. The specimens are used for polymorphism and tumor marker studies and oth
Sponsor: University of California, San Francisco

Current Primary Outcome: Factors related to glioma survival

Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: University of California, San Francisco

Dates:
Date Received: November 5, 2009
Date Started: October 2001
Date Completion:
Last Updated: May 14, 2015
Last Verified: May 2015