Clinical Trial: A Comparison of microRNA Samples in Patients With Nasal Polyps and Aspirin Exacerbated Respiratory Disease and Those With Nasal Polyps Only
Study Status: Completed
Recruit Status: Completed
Study Type: Observational
Official Title: A Comparison of microRNA Samples in Patients With Nasal Polyps and Aspirin Exacerbated Respiratory Disease and Those With Nasal Polyps Only
Brief Summary: We hypothesize that the miRNA expression in subjects with nasal polyps and Aspirin-exacerbated respiratory disease (AERD) differs from the miRNA expressed in subjects with nasal polyps but without Aspirin-exacerbated respiratory disease (AERD).
Detailed Summary: Nasal epithelial tissue will be collected from the inferior nasal turbinates of ten subjects with nasal polyps and AERD disease and from the inferior turbinates of ten subjects with nasal polyps but without AERD. A rhinoprobe™ will be used to collect this epithelial tissue. These samples will be analyzed by miRNA assay to determine if there is a difference in mircroRNA expression between the two subject groups.
Sponsor: University of South Florida
Current Primary Outcome:
- Positibe Group: 2 fold or greater will be identified as differntially expressed MiRNA. [ Time Frame: No time frame noted ]5 total groups
- Negative Group: MiRNAs are absent from both groups [ Time Frame: No time frame noted ]5 total groups
Original Primary Outcome:
Current Secondary Outcome:
Original Secondary Outcome:
Information By: University of South Florida
Dates:
Date Received: June 27, 2012
Date Started: August 2011
Date Completion:
Last Updated: October 6, 2014
Last Verified: October 2014
