Clinical Trial: Blood Pressure and Brain Blood Flow Regulation After Midodrine Administration in Those With Spinal Cord Injury

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Neural and Mechanical Baroreflex Sensitivity and Cerebral Blood Flow

Brief Summary: This project aims to evaluate the physiological effects of Midodrine administration during orthostatic challenge in those with high level spinal cord injury. Midodrine has been shown to improve orthostatic symptoms in those with spinal cord injury but the physiological mechanisms influenced have not been identified. The investiagtors will examine key physiological components influencing orthostatic tolerance. The investiagtors will do this, by measuring the baroreflex, and brain blood flow autoregulation (the ability to maintain brain blood flow) before during and after the sit-up test. Two sit-up tests will occur; one before Midodrine administration, and one after administration of a 10mg dose of Midodrine.

Detailed Summary:
Sponsor: University of British Columbia

Current Primary Outcome: Baroreflex sensitivity [ Time Frame: Immediately after drug administration (30 mins) ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Cerebral autoregulation [ Time Frame: Thirty minutes after administration ]

Original Secondary Outcome: Same as current

Information By: University of British Columbia

Dates:
Date Received: December 21, 2011
Date Started: March 2012
Date Completion:
Last Updated: March 14, 2014
Last Verified: March 2014