Clinical Trial: From ACute To Chronic Postoperative Pain in Patients for Elective Cholecystectomy
Study Status: Completed
Recruit Status: Completed
Study Type: Observational
Official Title: From Acute To Chronic Postoperative Pain in Patients for Elective Cholecystectomy: The Significance of Components of Pain
Brief Summary:
Chronic Pain is a wellknown complication after cholecystectomy. Intensity of the pain in the first week after the operation is a predictive factor for the development of chronic pain, but it is unknown whether the risk is more related to one of the different components of acute pain (ie somatic, visceral, referred). Furthermore the chronic pain has not been systematically described in terms of type of pain or sensory abnormalities etc. (allodynia, hyperalgesia etc.).
The purpose of the study is to examine whether intensity of components of acute pain is predictive for development of chronic pain after cholecystectomy and to characterize the chronic pain by quantitative sensory testing.
DNA-samples are collected to examine genetical factors, important for perception of pain, and the development of chronic pain.
Detailed Summary:
Sponsor: Odense University Hospital
Current Primary Outcome: Abdominal pain [ Time Frame: 12 months ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- Quantitative sensory testing values in referred pain area. [ Time Frame: 12 Months ]
Quantitative sensory testing values in referred pain area compared to contralateral side and preoperative values.
The following quantitative sensory tests are performed:
Cold Detection Threshold,Warm Detection Threshold, Cold Pain Threshold, Heat Pain Threshold, Mechanical detection Threshold, Mechanical Pain Threshold, Allodynia, Hyperalgesia, Wind-Up Ratio, Vibration Detection Threshold, Pressure Pain Threshold
- Abdominal pain [ Time Frame: 6 months ]
- Quantitative sensory testing values in referred pain area. [ Time Frame: 6 Months ]
Quantitative sensory testing values in referred pain area compared to contralateral side and preoperative values.
The following quantitative sensory tests are performed:
Cold Detection Threshold,Warm Detection Threshold, Cold Pain Threshold, Heat Pain Threshold, Mechanical detection Threshold, Mechanical Pain Threshold, Allodynia, Hyperalgesia, Wind-Up Ratio, Vibration Detection Threshold, Pressure Pain Threshold
Original Secondary Outcome:
- Quantitative sensory testing values in referred pain area. [ Time Frame: 12 Months ]
Quantitative sensory testing values in referred pain area compared to kontralateral side and preoperative values.
The following quantitative sensory tests are performed:
Cold Detection Threshold,Warm Detection Threshold, Cold Pain Threshold, Heat Pain Threshhold, Mechanical detection Threshhold, Mechanical Pain Threshold, Allodynia, Hyperalgesia, Wind-Up Ratio, Vibration Detection Threshold, Pressure Pain Threshold
- Abdominal pain [ Time Frame: 6 months ]
- Quantitative sensory testing values in referred pain area. [ Time Frame: 6 Months ]
Quantitative sensory testing values in referred pain area compared to kontralateral side and preoperative values.
The following quantitative sensory tests are performed:
Cold Detection Threshold,Warm Detection Threshold, Cold Pain Threshold, Heat Pain Threshhold, Mechanical detection Threshhold, Mechanical Pain Threshold, Allodynia, Hyperalgesia, Wind-Up Ratio, Vibration Detection Threshold, Pressure Pain Threshold
Information By: Odense University Hospital
Dates:
Date Received: March 2, 2012
Date Started: April 2010
Date Completion:
Last Updated: June 16, 2014
Last Verified: June 2014
