Clinical Trial: Trial of Pre-operative Chemoradiotherapy Followed by Surgical Resection in Pancoast Tumors (JCOG 9806)
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: A Phase II Trial of Pre-operative Chemoradiotherapy Followed by Surgical Resection in Pancoast Tumors: Initial Report of Japan Clinical Oncology Group Trial (JCOG 9806)
Brief Summary: The purpose of this study is to evaluate the safety and efficacy of the trimodality (concurrent chemoradiotherapy followed by surgical resection) approach in superior sulcus tumors.
Detailed Summary: Pre-operative radiotherapy has long been the community standard in Pancoast, or superior sulcus tumor. However, both complete resection rate (-50%) and long-term survival (-30%) are poor and unchanged for 40 years. Concurrent chemoradiotherapy has been shown to be beneficial in unresectable stage III non-small cell cancer. Surgery after induction chemoradiotherapy thus is a promising treatment strategy, and in fact, SWOG reported favorable results of this trimodality approach in superior sulcus tumor. The current trial is a Japanese, cooperative, multi-center, prospective one to evaluate its safety and efficacy.
Sponsor: Japan Clinical Oncology Group
Current Primary Outcome: 3-year survival rate
Original Primary Outcome: Same as current
Current Secondary Outcome:
- complete resection rate
- post-surgical morbidity/mortality
- local control rate
Original Secondary Outcome: Same as current
Information By: Japan Clinical Oncology Group
Dates:
Date Received: August 8, 2005
Date Started: May 1999
Date Completion: February 2006
Last Updated: September 20, 2016
Last Verified: September 2016
