Clinical Trial: Multi-center Clinical Study of Early Antibios of Severe Acute Pancreatitis

Study Status: Completed
Recruit Status: Unknown status
Study Type: Interventional

Official Title: Escalade or Deseacalade Antibiotic Use in Severe Acute Pancreatitis

Brief Summary: Strategy of antibiotic therapy in SAP,De-escalate (cefoperazone+metronidazole) or Escalate (meropenem) therapy,which one is better.

Detailed Summary:

SAP is a serious and life-threatening disease and requires intensive and aggressive management of multiple organ failure and severe infectious complications that can develop in these patients. The most common cause of death in patients suffering from severe acute pancreatitis (SAP) is the infection of pancreatic necrosis by enteric bacteria with mortality rates of 30% (range 14- 62%),spurring the discussion of whether or not prophylactic antibiotic administration could be a beneficial approach. Pancreatic infections are more often monomicrobial, especially E. coli in the two first weeks (100% and 62.5%) of onset, with a shift from gram-negative to gram-positive as the pancreatitis progressed.

In order to evaluate the benefit of prophylactic antibiotic application, a number of randomized controlled clinical trials have been published over the past 15 years. Since the results were conflicting and most studies were of low methodological quality and/or statistically underpowered, meta-analyses have been performed to assess this important issue. However, their results ranged from absolutely no effect of antibiotic prophylaxis to positive effects regarding mortality, the incidence of infected pancreatic necrosis and the incidence of extra pancreatic infections.

In order to provide reliable evidence of the effect of antibiotherapy strategy in SAP, we performed a prospective randomized multicenter clinical trial.


Sponsor: Erzhen Chen

Current Primary Outcome: pancreatic or peripancreatic infection [ Time Frame: 28-day ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

  • cost of management of SAP [ Time Frame: 90-day ]
  • Microbiology resistance [ Time Frame: 90-day ]
    sputum, urine and blood culture will be done once or twice per week if needed. bill or other culutre will be done when the patient is undergoing operation.


Original Secondary Outcome: Same as current

Information By: Ruijin Hospital

Dates:
Date Received: October 31, 2013
Date Started: July 2012
Date Completion: December 2016
Last Updated: November 18, 2013
Last Verified: November 2013