Clinical Trial: Squamous Cell Carcinoma Antigen Analysis at the University Hospital Ostrava

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Squamous Cell Carcinoma Antigen as a Marker of Sinonasal Inverted Papilloma

Brief Summary:

This prospective study aimed to evaluate the usefulness of squamous cell carcinoma antigen (SCCA) as a clinical marker of sinonasal inverted papilloma (IP). The potential benefit of SCCA in the diagnosis of unilateral nasal pathology and as a marker of hidden recurrence was evaluated as well.

Blood samples from patients with sinonasal IP were examined to determine serum SCCA levels before surgery, the day after surgery, and every 6 months during follow-up. Preoperative and postoperative levels of SCCA were compared.


Detailed Summary:

INTRODUCTION Squamous cell carcinoma antigen (SCCA) is a protein with a strong homology to the family of protease inhibitors known as serpins. SCCAs are cytoplasmic proteins: they are found in normal squamous epithelia, and in elevated levels in the serum of patients with squamous cell carcinomas, especially in cases of uterine cervix carcinoma, lung carcinoma, and head and neck squamous cell carcinoma. SCCA is clinically useful, especially for the staging of uterine cervix carcinoma (risk of lymph node metastasis). It is also a useful marker for monitoring during follow-up and therapy, and increasing SCCA levels may predict carcinoma relapse. Recent studies have shown a close relationship between SCCA and sinonasal inverted papilloma (IP).

IP is a relatively infrequent, benign sinonasal tumour. Careful long-term follow-up after radical surgery is necessary when treating IP, owing to its malignant potential and high recurrence rate. Distinguishing between inflammatory changes and recurrence of IP can sometimes be difficult. The purpose of this study was to determine the benefit of SCCA serum level evaluation in patients with IP.

MATERIAL AND METHODS Study design This prospective study was performed in accordance with the Declaration of Helsinki, the criteria of good clinical practice, and all applicable regulatory requirements. Written informed consent was obtained from all participants before the initiation of any procedure.

Patients with IP treated at the Department of Otolaryngology, Faculty of Medicine, University of Ostrava were included in the study. At least three years of follow-up after surgery was required for inclusion of a patient in the study.

Blood samples from enrolled patients were examined to determine serum
Sponsor: University Hospital Ostrava

Current Primary Outcome: Changes in blood levels of SCCA before and after surgical removal of sinonasal papiloma [ Time Frame: 1 week ]

The levels of SCCA were assessed before and after the surgical procedure.


Original Primary Outcome: Same as current

Current Secondary Outcome: Changes in blood levels of SCCA at six months after surgical removal of sinonasal papiloma [ Time Frame: 11 years ]

The levels of SCCA were assessed at six months after the surgical procedure and every six months during the follow-up period.


Original Secondary Outcome: Same as current

Information By: University Hospital Ostrava

Dates:
Date Received: March 22, 2013
Date Started: January 2000
Date Completion:
Last Updated: April 4, 2013
Last Verified: April 2013