Clinical Trial: Collecting and Storing Tissue Samples From Patients With Head and Neck Cancer

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Establishment of a Head and Neck Cancer Tissue/Specimen Bank

Brief Summary:

RATIONALE: Collecting and storing samples of tissue, blood, and saliva from patients with cancer to study in the laboratory may help the study of cancer in the future.

PURPOSE: This laboratory study is collecting and storing tissue samples from patients with head and neck cancer.


Detailed Summary:

OBJECTIVES:

  • Establish a tissue/specimen bank of biologic specimens collected from patients with proven or suspected head and neck cancer.
  • Establish a database to link materials acquisition and pathologic and clinical information on these patients.
  • Correlate clinical-pathological findings on these patients with future scientific studies using the patient database.
  • Test new hypotheses as they emerge.

OUTLINE: This is a prospective, multicenter study.

Patients enrolled on active Radiation Therapy Oncology Group clinical trials undergo biopsy or surgical resection of head and neck tumors or premalignant lesions at participating institutions. Tissue and other specimens collected at the time of biopsy or surgery are submitted to the Head and Neck Cancer Tissue/Specimen Bank which acts as a central repository for processing, storing, and preserving patient specimens for translational research. Tissue samples include paraffin-embedded blocks or fresh or frozen samples of normal squamous mucosa, tumors, or premalignant lesions of the upper aerodigestive tract. Other specimens for tissue banking include serum, plasma, and lymphocytes isolated from peripheral blood, as well as samples of patient saliva. Cells obtained from tissue bank specimens may also be used to establish cell lines for future research.

PROJECTED ACCRUAL: An unlimited number of specimens will be accrued for this study.


Sponsor: Radiation Therapy Oncology Group

Current Primary Outcome: Establishment of a Head and Neck Cancer Tissue/Specimen Bank [ Time Frame: From the start of enrollment to the end of enrollment; enrollment closed at 351 patients ]

Original Primary Outcome:

  • Establishment of a Head and Neck Cancer Tissue/Specimen Bank
  • Establishment of a database of patients participating in Radiation Therapy Oncology Group clinical trials
  • Resource for testing emerging scientific questions or assays


Current Secondary Outcome:

Original Secondary Outcome:

Information By: Radiation Therapy Oncology Group

Dates:
Date Received: May 9, 2009
Date Started: September 2005
Date Completion:
Last Updated: November 11, 2015
Last Verified: November 2015