Clinical Trial: The Nasal Airway in Chronic Obstructive Pulmonary Disease

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title: The Nasal Airway in Chronic Obstructive Pulmonary Disease

Brief Summary:

The study is based on the theory of a "unified airway" that considers the nose and paranasal sinuses together with lower airways as one integrated unit. The upper and lower respiratory tracts function as an interdependent physiologic mechanism, and stimuli that trigger changes in one portion of the airway, can provoke similar changes throughout the airway. This is well documented in asthmatic patients but documented poorly in patients suffering from chronic obstructive lung disease (COPD).

COPD is associated with sinonasal symptoms and decreased quality of life. Although nasal involvement has been found to directly affect the lower airway, sinonasal disease is under-diagnosed and under-treated in patients with COPD. This study is embedded in a larger project where the goal is to gain knowledge supporting the theory of a "unified airway" in patients with COPD.

Here sinonasal, pulmonary and generic health related quality of life will be studied in a group of patients with COPD versus a control group. The severity of nasal airway obstruction will be linked to the the severity of pulmonary airway obstruction. Assessment of pathological changes in the nose with nasal endoscopy, as well as performing a nasal cytological brushing for the identification of nasal inflammatory responses in the nose, will be conducted in both the control and study group.


Detailed Summary:
Sponsor: Norwegian University of Science and Technology

Current Primary Outcome:

  • pathological changes in the nose assessed with nasal endoscopy [ Time Frame: 4 hours ]
  • inflammatory responses in the nose identified by nasal cytological brushing [ Time Frame: 4 hours ]


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Norwegian University of Science and Technology

Dates:
Date Received: May 25, 2016
Date Started: February 2016
Date Completion: February 2018
Last Updated: January 9, 2017
Last Verified: January 2017