Clinical Trial: Measles, Mumps, and Rubella (MMR) Immunity in College Students
Study Status: Completed
Recruit Status: Completed
Study Type: Observational
Official Title: Persistence of Humoral and Cellular Immune Responses Following Age-appropriate Vaccination With the MMR Vaccine
Brief Summary: This study will lay the foundation for determining the underlying reasons for lack of immunity to mumps that led to the 2006 mumps outbreak on college campuses in the Mid West, and it will assess the potential for similar outbreaks of measles and rubella. A total of 70 to 80 college students (age 18 to 22) on the Emory campus (or nearby college campuses or the community) will be assessed for antibodies to measles, mumps or rubella by drawing a one-time blood sample. Their medical records will be verified for documentation of immunization with MMR vaccine prior to enrollment in the study. If a study volunteer is found to not have MMR immunity, they will be offered an MMR-II vaccine. For this group, additional blood specimens will be obtained.
Detailed Summary: No additional description needed.
Sponsor: Sri Edupuganti, MD MPH
Current Primary Outcome: Levels of mumps antibody and levels of memory B and T cell responses [ Time Frame: Day 1 for all participants except for those who receive MMR vaccine, there will be additional outcome measures on Day 0, 7, 14 and 28 post-vaccination. ]
Original Primary Outcome: Levels of mumps antibody and levels of memory B and T cell responses [ Time Frame: Day 1 for all participants except for those who receive MMR vaccine, there will be additional outcome measures on Day 0, 7, 14 and 28 post-vaccination. ]
Current Secondary Outcome: Determine proportion of college-aged students who are seronegative for mumps [ Time Frame: outcome measurement on Day 1 ]
Original Secondary Outcome: Determine proportion of college-aged students on the Emory Campus who are seronegative for mumps [ Time Frame: outcome measurement on Day 1 ]
Information By: Emory University
Dates:
Date Received: May 19, 2008
Date Started: March 2010
Date Completion:
Last Updated: March 4, 2014
Last Verified: March 2014