Clinical Trial: Sleep, Physical Activity and Multiple Sclerosis Symptoms in Pediatric Multiple Sclerosis

Study Status: Not yet recruiting
Recruit Status: Not yet recruiting
Study Type: Observational

Official Title: Sleep, Physical Activity and Multiple Sclerosis Symptoms in Pediatric Multiple Sclerosis

Brief Summary: Most youth with MS experience symptoms such as depression and fatigue. In addition, cognitive issues, especially with attention and memory occur frequently. However, little is known about interventions that might work to improve these symptoms. In other work. the investigators have shown that higher levels of physical activity are associated with lower levels of depression and fatigue. Importantly, sleep problems are frequently encountered in youth with MS, and were seen in 60% of surveyed youth with MS in the investigators preliminary work. Whether sleep plays an important role in symptoms in youth with MS, and the relationship between sleep and physical activity in youth with MS is unknown.

Detailed Summary:
Sponsor: The Hospital for Sick Children

Current Primary Outcome:

  • Quality, duration and timing of sleep will be determined by wearing the Actiwatch for 24 hours/day for seven days. [ Time Frame: 7-days ]
  • Children's Behavior Check List Sleep Composite [ Time Frame: 5 minutes ]
  • Pediatric Sleep Questionnaire [ Time Frame: 5 minutes ]
  • Physical activity will be observed through wearing an Accelerometer daily for 7-days. [ Time Frame: 7-days ]
  • The Varni Pediatric Multidimensional Fatigue Scale (PedsQL-MFS) [ Time Frame: 3 minutes ]
    A validated 18-item, self-rated symptom-oriented scale suitable for youths aged eight-18 that includes fatigue subscales (total, general, sleep/rest and cognitive fatigue).
  • The Epworth Sleepiness Scale [ Time Frame: 3 minutes ]
    A validated scale for children that will be used to derive contextual information about daytime fatigue as it relates to sleep.
  • The Centre for Epidemiological Studies Depression Scale Children's Rating Scale (CES-DC) [ Time Frame: 3 minutes ]
    A 20-item, self-rated, symptom-oriented scale suitable for people aged six to 23.
  • Neurological Exam Standard physical exam performed by neurologist to determine the Expanded Disability Status Scale (EDSS) score [ Time Frame: 20 minutes ]
  • Clinical Interview [ Time Frame: 10 minutes ]
    Series of questions about the participant's

    Original Primary Outcome: Same as current

    Current Secondary Outcome:

    Original Secondary Outcome:

    Information By: The Hospital for Sick Children

    Dates:
    Date Received: January 3, 2017
    Date Started: June 2017
    Date Completion: May 2018
    Last Updated: February 23, 2017
    Last Verified: February 2017