Clinical Trial: The Role of Novel Organisms in Acute Endometritis

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Characterization of Novel Organisms in the Genital Tract of Women With PID and Determination of Their Association With Endometritis.

Brief Summary: The goal of this project is to identify the microorganisms present in the endometrial samples obtained from women with or without evidence of endometritis using a combination of culture methods, rRNA sequencing and whole genomic sequencing. The overarching aim of these studies is to identify the etiology of endometritis. The investigators will define the role of fastidious anaerobic microorganisms in the etiology of PID, and assess whether antibiotic treatment regimens used for the treatment of PID have activity against the novel organisms linked with pelvic infections.

Detailed Summary:
Sponsor: Sharon Hillier

Current Primary Outcome:

• Identification of Novel Organsims from PRO10010159 [ Time Frame: 12 months after participant enrollment in PRO10010159 ]
  This study will use optimized culture methods which can support the growth of fastidious organisms to describe the microorganisms in endometrial tissue samples obtained from the 200 women enrolled in the cervicitis cohort (PRO10010159, T Cell Response).
• Identification of Novel Organisms from PRO10010112 [ Time Frame: 30 days after participant enrollment in PRO10010112 ]
  This study will use optimized culture methods which can support the growth of fastidious organisms to describe the microorganisms in endometrial tissue samples obtained from 250 women enrolled in the acute PID study before and after treatment (PRO10010112, Acute PID treatment).

Original Primary Outcome:

Current Secondary Outcome:

Original Secondary Outcome:

Information By: University of Pittsburgh

Dates:
Date Received: November 4, 2010
Date Started: November 2010
Date Completion:
Last Updated: August 15, 2016
Last Verified: August 2016