Clinical Trial: Safety Study of PI-0824 to Treat Pemphigus Vulgaris

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: An Open-Label, Dose-Escalation, Phase I Clinical Study to Assess the Safety of PI-0824 in Patient With Pemphigus Vulgaris Requiring Daily Corticosteroid Therapy

Brief Summary: The purpose of this study is to determine if the use of PI-0824 in patients with Pemphigus vulgaris is safe.

Detailed Summary: Pemphigus vulgaris (PV) is an autoimmune disease affecting approximately 40,000 people worldwide. People with PV produce antibodies that attack the cells of the skin, resulting in blisters which, if left untreated, can lead to devastating infections and discomfort. Currently, most doctors who treat patients with PV will prescribe high-dose steroids and drugs that suppress the immune system in an effort to decrease the production of these antibodies. Unfortunately these medications are associated with serious and difficult side effects that often result in the discontinuation of their use. Peptimmune, Inc. has developed a new therapy for the treatment of PV, PI-0824. The goal of this therapy is to reduce the production of antibodies that cause PV blisters by acting only on the disease causing components of the immune system. It is hoped that use of PI-0824 will reduce or potentially eliminate the need for high dose steroids and drugs that suppress the immune system.
Sponsor: Peptimmune

Current Primary Outcome:

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Information By: Peptimmune

Dates:
Date Received: July 3, 2003
Date Started: July 2003
Date Completion: March 2005
Last Updated: June 23, 2005
Last Verified: April 2005