Clinical Trial: A Comparison of Two Therapeutic Strategies for the Treatment of Aspirin-associated Peptic Ulcers

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: A Comparison of Two Therapeutic Strategies for the Treatment of Aspirin-associated Peptic Ulcers

Brief Summary: Esomeprazole plus aspirin compared with esomeprazole alone for the treatment of aspirin-related peptic ulcers.

Detailed Summary:

The aims of this study are to compare esomeprazole plus aspirin with esomeprazole alone in the treatment of aspirin-related ulcers.

Patients with aspirin-related peptic ulcers are randomized to receive esomeprazole (40 mg/day) plus aspirin (100 mg/day) or esomeprazole (40 mg/day) alone for 8 weeks. Follow-up endoscopy was carried out at the end of the eighth week. The primary end point was the healing of peptic ulcers.


Sponsor: Kaohsiung Veterans General Hospital.

Current Primary Outcome: Number of Participants in Whom Peptic Ulcer Was Healed [ Time Frame: 8 weeks ]

Number of participants in whom peptic ulcer was healed at week 8


Original Primary Outcome: Rate of Ulcer Healing [ Time Frame: 8 weeks ]

ulcer healing rate at week 8


Current Secondary Outcome: Number of Participants Deveoping Peptic Ulcer Bleeding [ Time Frame: 8 weeks ]

Number of participants deveoping peptic ulcer bleeding during 8-week study period


Original Secondary Outcome: Rate of Peptic Ulcer Bleeding [ Time Frame: 8 weeks ]

rate of peptic ulcer bleeding within 8-week study period


Information By: Kaohsiung Veterans General Hospital.

Dates:
Date Received: May 11, 2011
Date Started: June 2007
Date Completion:
Last Updated: September 12, 2016
Last Verified: September 2016