Clinical Trial: Natural History of Non-steroidal Anti-inflammatory Drug and Non-Helicobacter Pylori in Bleeding Peptic Ulcers

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: A Prospective Cohort Study to Study the Natural History and Ulcer Recurrence Without Acid Suppression of Non-NSAID, Non-HP Bleeding Peptic Ulcer Patients

Brief Summary: The aim of this study is to study the natural history of the ulcer healing while on proton pump inhibitors (PPI) and the ulcer recurrence without acid suppression therapy of Non-steroidal Anti-inflammatory Drugs (NSAID), non-Helicobacter pylori (HP) bleeding ulcer patients.

Detailed Summary: Non-steroidal Anti-inflammatory Drugs (NSAID), Non-Helicobacter pylori (HP) bleeding peptic ulcers are relatively common in the West (11%-44%). It is uncommon in Hong Kong (4%). Significant number of these patients with non-NSAID, non-Hp bleeding ulcers had co-morbid illness and many had life-threatening conditions. Our recent study showed that there is an increasing incidence of non-steroidal anti-inflammatory drugs (NSAID), non-Helicobacter pylori (Hp) bleeding peptic ulcers. There is no datum on the natural course of these patients and this is our aim to have this observational study.
Sponsor: Chinese University of Hong Kong

Current Primary Outcome: Recurrent ulcer bleeding [ Time Frame: During the observation period ]

Original Primary Outcome:

Current Secondary Outcome: All-cause mortality [ Time Frame: During the observation period ]

Original Secondary Outcome:

Information By: Chinese University of Hong Kong

Dates:
Date Received: September 8, 2005
Date Started: August 2002
Date Completion:
Last Updated: February 28, 2013
Last Verified: February 2013