Clinical Trial: Effect of Preoperative Clindamycin on Postoperative Endodontic Pain

Study Status: Not yet recruiting
Recruit Status: Not yet recruiting
Study Type: Interventional

Official Title: Effect of Preoperative Single-dose Clindamycin on Postoperative Endodontic Pain in Patients With Symptomatic Apical Periodontitis: A Randomized Controlled Trial

Brief Summary: The aim of this prospective, randomized, placebo controlled study is to evaluate the effect of clindamycin on post-operative pain and swelling in adult patient with symptomatic apical periodontitis.

Detailed Summary:

Medical and dental history will be obtained from all patients participating in this trial. Clinical and radiographic evaluation for each tooth included in this study will be recorded.

Clinical diagnosis of symptomatic apical periodontitis is to be confirmed.

Before root canal treatment, eligible participants will be randomly assigned to one of the following groups: experimental group (taking 600 mg of clindamycin orally) or control group (taking placebo ) 30 minutes before the start of the treatment. Single-visit root canal treatment will be performed.

Each patient will receive a 7-day diary to record postoperative pain and swelling.In case of pain, the participant will be instructed to take an analgesic. Post-operative pain will be measured as a primary outcome on 11-point scale (NRS) at the following time points: 6, 12, 24, 48, 72 hours and 7 days. The occurrence of swelling will be reported by participant as a secondary outcome

Sponsor: Cairo University

Current Primary Outcome: Post-operative pain [ Time Frame: Up to 7 days after endodontic treatment ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Swelling [ Time Frame: 7 days ]

Original Secondary Outcome: Same as current

Information By: Cairo University

Dates:
Date Received: January 24, 2017
Date Started:
Date Completion:
Last Updated: January 26, 2017
Last Verified: January 2017