Clinical Trial: Antibacterial Effectiveness of Two Root Canal Irrigants
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Antibacterial Effectiveness of Two Root Canal Irrigants in Root-filled Teeth With Infection: A Randomized Clinical Trial
Brief Summary: The aim of this randomized clinical trial is to compare the antibacterial effects of 1% sodium hypochlorite (NaOCl) and 2% chlorhexidine gluconate (CHX) during retreatment of teeth with apical periodontitis (AP).
Detailed Summary: Root canal-treated teeth with AP were randomly distributed in two groups according to the irrigant used. After removal of the previous filling material, bacteriological samples were taken from the canals before (S1) and after chemomechanical preparation using either NaOCl or CHX (S2), and after calcium hydroxide medication for 2-3 weeks (S3). 16S rRNA gene-based real-time qPCR was performed to detect and quantify total bacteria, Streptococcus species and Enterococcus faecalis.
Sponsor: University of Oslo
Current Primary Outcome: Periapical radiolucency (PAI- and Friedman-scores) [ Time Frame: 12 months ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- Bacterial load assessed by qPCR [ Time Frame: 21 days ]
- Pyrosequencing of species found before and after the intervention [ Time Frame: 21 days ]
Original Secondary Outcome: Same as current
Information By: University of Oslo
Dates:
Date Received: March 21, 2016
Date Started: January 2012
Date Completion:
Last Updated: April 18, 2016
Last Verified: April 2016
