Clinical Trial: Septal Shift for the Diagnosis of COnstrictive Pericarditis: The Impact of Inspiratory Effort Quantification on Deep Breathing Manoeuvres

Study Status: Not yet recruiting
Recruit Status: Not yet recruiting
Study Type: Observational

Official Title: Septal Shift for the Diagnosis of COnstrictive Pericarditis: The Impact of Inspiratory Effort Quantification on Deep Breathing Manoeuvres (SCOPED)

Brief Summary: This study will evaluate the effect of deep breathing manoeuvres on inter ventricular interdependency physiology. By providing further insight in this basic physiology we want to add more comprehensive data in favor or not of constrictive pericarditis diagnostic criteria currently used in cardiovascular magnetic resonance.

Detailed Summary:
Sponsor: Université de Sherbrooke

Current Primary Outcome: Measurement of the interventricular septum position between inspiration and expiration as assessed by CMR. [ Time Frame: Immediate ]

Analysis of respiratory-related septal excursion. The relative position of the septum can be obtained by dividing the distance between RV free wall and septum by the biventricular distance. If done during inspiration and expiration, at early ventricular filling, the respiratory-related septal excursion can be quantified.


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Presence or absence (categorical variable) of a diastolic bounce as assessed by CMR. [ Time Frame: Immediate ]
    Diastolic bounce corresponds to a displacement of inter ventricular septum towards de left ventricle during the protodiastolic period.
  • Measurement of the variation of flow through the mitral and tricuspid valve between inspiration and expiration as assessed by CMR. [ Time Frame: Immediate ]
    Real-Time Phase-Contrast acquisition using a custom-made sequence with through-plane velocity encoding to simultaneously measure MV and TV inflow velocities by prescribing a slice position across both atrioventricular valves from a horizontal long-axis view.
  • Biventricular Index: measurement of the heart contour between inspiration and expiration as assessed by CMR. [ Time Frame: Immediate ]
    Short axis cross section through the mid ventricle. The epicardial tracings is performed in end expiration and end inspiration. The end inspiratory epicardial tracing is divided by the end expiratory epicardial tracing to obtain the biventricular index
  • Presence or absence (categorical variable) of diastolic flow reversal in inferior vein cave as assessed by cardiovascular magnetic resonance (CMR). [ Time Frame: Immediate ]
    Real-time cine imaging of the inferior vein cave for 10 s
  • Presence or Absence of lack of myocardial slippage in relation to the pericardium as assessed by CMR (tagging sequence) [ Time Frame: Immediate ]
    Four-chamber tagged cardiac magnetic resonance image showing lack of slippage between parietal and visceral pericardia. The tag lines break between parietal and visceral pericardia during the cardiac cycle in a normal heart. In constrictive pericarditis, the tag lines do not break.
  • Measurement of the relative atrial volume ratio as assessed by CMR. [ Time Frame: Immediate. ]
    The relative atrial volume ratio (RAR) is defined as the left auricular (LA) volume divided by right auricular (RA) volume. For the LA volume, the biplane area- length method will be used. For the RA volume, the monoplane area-length formula will be used.


Original Secondary Outcome: Same as current

Information By: Université de Sherbrooke

Dates:
Date Received: January 13, 2016
Date Started: February 2016
Date Completion:
Last Updated: February 12, 2016
Last Verified: February 2016