Clinical Trial: Periodontal Disease and Circulatory Microbial Components

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Circulatory Microbial Components and Immune Regulators of Patients With Periodontal Disease and Rheumatoid Arthritis

Brief Summary: The goal of this project is to study the immune activity of certain proteins present in the blood of patients with severe periodontal disease. Periodontal disease (gum disease) is the major cause of tooth loss among adults. Moderate to severe periodontal disease is reported to affect 5-15% of American adults. It begins with an infection of the tissues surrounding the teeth, and leads to a worsening inflammatory response. This study will aid in clarifying the way in which gum disease might affect certain systemic diseases.

Detailed Summary: This project will have two specific goals: 1. Identify microorganism components in the serum of patients with severe periodontitis; and 2. Characterize the immune regulator activity of periodontitis serum. This proposed feasibility study will then aid in providing the support for an increased sample size and other design requirements for larger, more expanded human clinical trial testing.In this study, forty (40) subjects will be divided into 2 groups: 1) Healthy oral status group and 2) Severe periodontal disease. Patients will be clinically screened using standard periodontal measurements.
Sponsor: University of Michigan

Current Primary Outcome: Identify microorganism components in the serum of patients with severe periodontitis [ Time Frame: 1hour ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Characterize the immune regulator activity of periodontitis serum [ Time Frame: 1 hour ]

Original Secondary Outcome: Same as current

Information By: University of Michigan

Dates:
Date Received: March 16, 2010
Date Started: January 2010
Date Completion:
Last Updated: December 11, 2015
Last Verified: December 2015