Clinical Trial: Compare the Efficacy of Aloe Vera Mouthwash With Non- Alcoholic Chlorhexidine Mouthwash on Periodontal Diseases

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Randomized, Clinical Trial to Evaluate the Effects of Aloe Vera Mouthwash in Comparison With Non-alcoholic Chlorhexidine on Periodontal Disease

Brief Summary:

Aim: To compare the efficacy of Aloe Vera and non-alcoholic chlorhexidine mouthwash in the treatment of Periodontal diseases.

Methods &Material: 32 patients were selected, the following periodontal parameters were recorded at baseline, and after recording all the parameters at the baseline, Scaling, root planning, and polishing are done for all the patients participating in the study. Oral hygiene instructions were given that included brushing twice a day with a soft brush, After 2 weeks, patients in the study, were randomly (Balanced Block Randomization) equal divided into 2 groups;

Group A: mouthwash aloe Vera (Alodent Co. UK) for each patient, Group B: Non-alcoholic Chlorhexidine (Perio-Kin, Livar CO. Spain) 10 ml by patients routinely washed two times in one day for about 30 seconds and lasts for 15 days, then every 7 days periodontal parameters, and at the end of 2 weeks (days 0, 7, 15) clinical changes are evaluated.


Detailed Summary:

Eligible participants were 32 adult patients treated for chronic periodontitis and participating in a supportive periodontal therapy program at the Department of Periodontology of the Dental Clinic of the Islamic Azad University, Dental Branch of Tehran were included in the current study; Recruitment of participants started july 2014 and ended may 2015. The study met the criteria of the Helsinki Declaration of 1975, revised in 2008. The survey plan was reviewed and sanctioned, approved by the ethics commission of the Institutional Ethical Committee and Review Board of the Deputy of Research, School of Dentistry. All subjects received the oral and written explanation of the intent of the survey and signed an informed consent after receiving detailed information about the purpose, the benefits, and the possible risks associated with the trial. Individuals satisfying the following entry criteria were recruited:

  • Diagnosed suffering from initial (early) to moderate chronic periodontitis;
  • Adult patients, more than 28 years old with at least 20 remaining teeth and at least three teeth in each quadrant;
  • The presence of at least two residual sites with a probing pocket depth (PPD>4 mm in two opposite quadrants, which showed bleeding upon probing, radiographically comparable amount of periodontal breakdown and good matching in tooth type, also clinical and minimal radiographic signs of initial (early) to moderate (clinical attachment level of 1 to 3mm.

Sponsor: Islamic Azad University, Tehran

Current Primary Outcome: Reduction of pocket depth [ Time Frame: 7days ]

Periodontal pobe


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Reduction of bleeding on probing [ Time Frame: 7days ]
    Periodontal pobe
  • Reduction of plaque index [ Time Frame: 7days ]
    Plaque Index(O'Leary )


Original Secondary Outcome: Same as current

Information By: Islamic Azad University, Tehran

Dates:
Date Received: September 24, 2015
Date Started: March 2014
Date Completion:
Last Updated: June 3, 2016
Last Verified: June 2016