Clinical Trial: Advanced Oxidation Protein Product and Monocyte Chemoattractant Protein-1 in Periodontal Disease
Study Status: Completed
Recruit Status: Completed
Study Type: Observational
Official Title: The Levels of Advanced Oxidation Protein Product and Monocyte Chemoattractant Protein-1 in Gingival Crevicular Fluid in Periodontal Disease and Health
Brief Summary: This study investigates the levels of advanced oxidation protein product and monocyte chemoattractant protein-1 in gingival crevicular fluid in periodontal disease and health. 25 participants with chronic periodontitis, 25 participants with gingivitis and 25 periodontally healthy subjects are included into this study. In each participant, four sites are identified for gingival crevicular fluid samples.
Detailed Summary:
Oxidative stress is the disequilibrium between the formation of free radicals and antioxidant defense mechanisms via damaging cellular macromolecules (DNA, protein, lipid, etc..) which are susceptible to oxidative damage.
Advanced oxidation protein product is identified as a new marker of protein oxidation.
Monocyte chemoattractant protein-1 is a major chemoattractant for lymphocytes, monocytes and macrophages.
Sponsor: Kırıkkale University
Current Primary Outcome: Advanced oxidation protein product (nmol) [ Time Frame: Before periodontal treatment ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- Monocyte chemoattractant protein-1(pg) [ Time Frame: Before periodontal treatment ]
- The probing depth (mm), clinical attachment level (mm), plaque index scores (0-3) and gingival index scores (0-3) [ Time Frame: Before periodontal treatment ]
Original Secondary Outcome: Same as current
Information By: Kırıkkale University
Dates:
Date Received: July 21, 2016
Date Started: May 2014
Date Completion:
Last Updated: July 25, 2016
Last Verified: July 2016
