Clinical Trial: Effect of Disinfective Solution as an Adjunct to Maintenance Therapy of Inflamed Periodontal Pockets

Study Status: Not yet recruiting
Recruit Status: Unknown status
Study Type: Interventional

Official Title: Using Chemical Pocket Disinfection as an Adjunct to Non-surgical Maintenance Therapy of Inflamed Periodontal Pockets

Brief Summary: The purpose of this study is to determine whether the adjunctive use of chemical pocket disinfection with scaling and root planing is more effective than scaling and root planing alone in clinically reducing periodontal probing depth (PD), reducing bleeding on probing (BOP), and gaining clinical attachment level (CAL). It also will assess whether chemical pocket disinfection with scaling and root planing will have an effect on biomarkers of inflammation, as indicated by presence of pro- and anti-inflammatory cytokines, compared to scaling and root planing alone. The chemical pocket disinfection therapy consists of delivering a sodium hypochlorite solution followed by a neutralizing citric acid solution to the test site.

Detailed Summary: Pro-inflammatory interleukin-1 beta and anti-inflammatory interleukin-1 receptor antagonist will be measured from the gingival crevicular fluid sampled from sites of interest.
Sponsor: University of Nebraska

Current Primary Outcome: Probing depths [ Time Frame: 3 months ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Bleeding on probing [ Time Frame: 3 months ]
  • Clinical attachment level [ Time Frame: 3 months ]
    Clinical attachment level is calculated by adding gingival recession to probing depth; measures the connective tissue and epithelial attachment level relative to the cementoenamel junction
  • Inflammatory markers [ Time Frame: 3 months ]
    Measure interleukin-1 beta and interleukin 1 receptor antagonist levels in gingival crevicular fluid from sites of interest


Original Secondary Outcome: Same as current

Information By: University of Nebraska

Dates:
Date Received: December 8, 2014
Date Started: October 2013
Date Completion: June 2015
Last Updated: December 10, 2014
Last Verified: December 2014