Clinical Trial: Whole Body Magnetic Resonance Imaging With Diffusion Weighted Imaging : Potential Role in Neurofibromatosis
Study Status: Active, not recruiting
Recruit Status: Unknown status
Study Type: Observational
Official Title: Whole Body Magnetic Resonance Imaging With Diffusion Weighted Imaging : Potential Role in Neurofibromatosis
Brief Summary:
Whole body MRI will be performed in patients with neurofibromatosis Type 1
PURPOSE 1:
To determine the total tumor load (neurofibroma) and to diagnose plexiform neurofibromas or malignant peripheral nerve sheath tumors. All patients will be scanned two years after the baseline whole body MRI to investigate to investigate the changes of total tumor load.
PURPOSE 2: added value of diffusion weighted imaging in diagnosis of high-risk neurofibromas
PURPOSE 3 : to determine the apparent diffusion coefficient of the malignant nerve sheath tumors and neurofibroma.
PURPOSE 4 : correlation between histopathology of the surgically resected neurofibroma/malignant nerve sheath tumors and MRI findings
Detailed Summary:
Sponsor: Universitaire Ziekenhuizen Leuven
Current Primary Outcome: Estimation of total tumor load and diagnosis of high-risk neurofibromas [ Time Frame: 1 month ]
Original Primary Outcome: Same as current
Current Secondary Outcome: To diagnose high-risk neurofibroma [ Time Frame: 2 months ]
Original Secondary Outcome: Same as current
Information By: Universitaire Ziekenhuizen Leuven
Dates:
Date Received: January 23, 2013
Date Started: December 2010
Date Completion: January 2014
Last Updated: January 23, 2013
Last Verified: January 2013