Clinical Trial: Amyloid Plaque and Tangle Imaging in Aging and Dementia

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Amyloid Plaque and Tangle Imaging in Aging and Dementia

Brief Summary: Amyloid senile plaques (SPs) and neurofibrillary tangles (NFTs) are neuropathological hallmarks of Alzheimer's disease (AD) that also accumulate in key brain regions in association with normal aging. This project will expand an established program in early detection and prevention of AD designed (1) to identify presymptomatic persons most likely to benefit from early intervention and (2) to provide an objective, noninvasive means to monitor therapeutic trials.

Detailed Summary: A total of 194 volunteers will be recruited for this 2-year study. Participants will receive a baseline clinical and imaging evaluation and one follow-up evaluation two years later. These evaluations will include clinical and neuropsychological assessments, structural MRI and/or PET scans. Additional scans and scanning procedures will be performed on a subset of participants and participant visits, including serotonin density levels.
Sponsor: University of California, Los Angeles

Current Primary Outcome:

Original Primary Outcome:

Current Secondary Outcome:

Original Secondary Outcome:

Information By: University of California, Los Angeles

Dates:
Date Received: July 20, 2006
Date Started: September 2005
Date Completion:
Last Updated: December 2, 2015
Last Verified: December 2015