Clinical Trial: Atherosclerotic Plaque Characterization

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Atherosclerotic Plaque Characterization Using Multispectral, Multicontrast High Resolution Cardiovascular Magnetic Resonance Imaging

Brief Summary: The purpose of this study is to utilize high-resolution CMR carotid imaging for the characterization of carotid wall volumes and plaque content in patients with clinical significant carotid atherosclerosis. Patients who are scheduled to undergo an imaging procedure will be recruited from the cath lab. Upon enrollment, blood samples conventional and genetic profiling will be collected. For patients undergoing a carotid endarterectomy, tissue from the carotid vessel will be collected during their procedure. Comparison of the MR images with tissue and/or blood samples will be made. Length of time in the study will be approximately 1 day. There will be no study-related patient follow-up.

Detailed Summary:
Sponsor: Piedmont Healthcare

Current Primary Outcome: Characterization of plaque that is found in the carotid walls of patients who have atherosclerosis [ Time Frame: 2 years post study initiation ]

Original Primary Outcome: Characterization of plaque that is found in the carotid walls of patients who have atherosclerosis [ Time Frame: 1 Year ]

Current Secondary Outcome: To evaluate the effectiveness of MR imaging in identifying these plaque characteristics [ Time Frame: 2 Years Post Study Initiation ]

Original Secondary Outcome: To evaluate the effectiveness of MR imaging in identifying these plaque characteristics [ Time Frame: 1 Year ]

Information By: Piedmont Healthcare

Dates:
Date Received: March 11, 2009
Date Started: October 2006
Date Completion:
Last Updated: April 14, 2014
Last Verified: April 2014