Clinical Trial: Ceftriaxone Vs Levofloxacin on Cytokine Expression in Pneumococcal Pneumonia

Study Status: Terminated
Recruit Status: Terminated
Study Type: Interventional

Official Title: Comparison Between Ceftriaxone and Levofloxacin on Cytokine Expression Over Time in Severe Pneumococcal Pneumonia

Brief Summary: The purpose of this study is to compare levofloxacin vs ceftriaxone impact on the cytokine production in patients with pneumococcal pneumonia.

Detailed Summary:

Bacterial alveolar invasion is followed by a compartmentalized inflammatory response. Data suggest that some antimicrobials may induce a differential release of cytokines, with the potential of either accelerating or down regulating cytokine production.

The aim of our study was to compare the effects of ceftriaxone compared with levofloxacin on cytokine systemic concentrations in patients with pneumococcal pneumonia.

Sponsor: Hospital Mutua de Terrassa

Current Primary Outcome: Circulating levels of pro and anti-inflammatory cytokines at 0h, 24, 72 h and 120 h from inclusion

Original Primary Outcome: Same as current

Current Secondary Outcome: the relationship between cytokine expression, clinical variables and severity of disease.

Original Secondary Outcome: Same as current

Information By: Hospital Mutua de Terrassa

Dates:
Date Received: January 31, 2007
Date Started: August 2004
Date Completion: September 2005
Last Updated: January 31, 2007
Last Verified: January 2007