Clinical Trial: Use of TREM-1 Protein to Differentiate Viral and Bacterial Pneumonias in Intubated Children
Study Status: Terminated
Recruit Status: Unknown status
Study Type: Observational
Official Title: Use of a Novel Protein (sTREM-1) to Differentiate Pure Viral Lung Infection From Viral With co-Existing Bacterial Lung Infection
Brief Summary: The purpose of this study is to determine whether a protein called TREM-1 can be used to differentiate viral and bacterial pneumonias in children who are on ventilator support. We propose that the level of TREM-1 will be significantly elevated in the lung fluid of children with bacterial pneumonia and viral with co-existing bacterial pneumonia than in children with pure viral pneumonia.
Detailed Summary:
Most often, viruses are the cause of pneumonia in children. However, viral pneumonias are frequently associated with secondary bacterial pneumonia. It is important, though difficult, to differentiate patients who only have viral pneumonia from those who have viral pneumonia with secondary bacterial pneumonia. This will help physicians to prescribe antibiotics to only those with bacterial pneumonia and avoid antibiotic use in those with pure viral pneumonia, thus help to limit health-care cost and to decrease emergence of antibiotic resistance. In adult studies, TREM-1 has been shown to be specifically expressed in bacterial infections.
We propose that measuring TREM-1 in the bronchoalveolar lavage (BAL) fluid will help to differentiate these groups. Our hypothesis is that concentration of TREM-1 will be significantly elevated in the BAL fluid of children with bacterial pneumonia and viral with co-existing bacterial pneumonia than in children with pure viral pneumonia.
Sponsor: University of Texas Southwestern Medical Center
Current Primary Outcome: TREM-1 level in the BAL fluid of patients with pure viral pneumonia in comparison to patients with viral with co-existing bacterial pneumonia [ Time Frame: Within 48 hours of being intubated ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- TREM-1 level in the BAL fluid of patients with pure bacterial pneumonia and no pneumonia [ Time Frame: Within 48 hours of intubation for TREM-1 level ]
- TREM-1 level in the serum of all 4 groups [ Time Frame: Within 48 hours of intubation for TREM-1 level ]
- Length of ventilator support, length of ICU and hospital stay [ Time Frame: Within 48 hours of intubation for TREM-1 level ]
Original Secondary Outcome: Same as current
Information By: University of Texas Southwestern Medical Center
Dates:
Date Received: March 24, 2008
Date Started: November 2007
Date Completion: June 2009
Last Updated: March 26, 2008
Last Verified: March 2008
