Clinical Trial: The Impact of Simultaneous Presence of Viral and Bacterial Pathogens on Therapy and Course of Severe Pneumonia

Study Status: Completed
Recruit Status: Unknown status
Study Type: Observational

Official Title: The Impact of Simultaneous Presence of Viral and Bacterial Pathogens on Therapy and Course of Severe Pneumonia

Brief Summary: The purpose of the study is to determine if the clinical course of pneumonia is more severe when both, bacterial and viral pathogens are find as possible causative agent and how does it affect treatment.

Detailed Summary:

Basic demographic data of the patients (age, gender), data on concomitant diseases and epidemiological circumstances will be collected

Severity of illness will be assessed by APACHE II (at day 1) and SOFA (at day 1,2,3 and 7) scoring system

Following laboratory tests will be performed at day 1, 2,3 and 7.:

  • blood count analysis
  • differential blood count
  • C- reactive protein, procalcitonin
  • glucose, urea, potassium, sodium, chloride, magnesium, creatinine, bilirubin, protein, albumin, alkaline phosphatase, aspartate aminotransferase, alanine transaminase, gamma-glutamyl transpeptidase , alpha-amylase, lipase, creatine kinase, lactate dehydrogenase, myoglobin
  • arterial blood gas analysis
  • tests of hemostasis.

Additional 2 mL of blood will be taken at day 1 and day 21 (or later), due to paired serologic testing

To establish the presence of potential pathogens we will perform following microbiological investigations:

  • cultivation of 2 pairs of blood cultures in all patients
  • cultivation of sputum or quantitative cultivation of tracheal aspirate in nonintubated patients
  • quantitative cultivation of tracheal aspirate or bronchoalveolar lavage in intubated patients
  • testing the presence of soluble Legionella antigen in urine in all patients
  • testing the presence of
    Sponsor: University Medical Centre Ljubljana

    Current Primary Outcome: Rate of changes in empirical antibiotic therapy due to broad microbiological diagnostic [ Time Frame: each patient will be assessed at enrollment and follow-up for 2 months ]

    Original Primary Outcome: Same as current

    Current Secondary Outcome:

    Original Secondary Outcome:

    Information By: University Medical Centre Ljubljana

    Dates:
    Date Received: July 25, 2014
    Date Started: January 2014
    Date Completion: March 2016
    Last Updated: July 25, 2014
    Last Verified: July 2014