Clinical Trial: Interventional Treatment of Refractory Pneumothorax by Bronchoscope

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: A Multi-site Randomized Controlled Study of Interventional Treatment of Refractory Pneumothorax by Bronchoscope

Brief Summary: The purpose of this study is to determine whether injecting autologous blood or putting bronchial plug through bronchoscope is effective in the treatment of refractory pneumothorax.

Detailed Summary: This is a multi-site, controlled, randomized study. Refractory pneumothorax is a challenge for respiratory physicians. Many patients present recurrent pneumothorax. Thoracic closed drainage is a basic and effective treatment to pneumothorax. Chronic obstructive pulmonary disease(COPD)is one of the main causes of spontaneous pneumothorax. Many patients precluded the performance of surgery for poor pulmonary function. In China, economical load is another reason for patients who are unwilling to surgery. So we want to seek a cheap, effective and safe method for refractory pneumothorax. We will adopt three methods in this study. Conventional thoracic closed drainage was continuously used in the control group, autologous blood was perfused to the target pulmonary segment in the treatment A group and self-made silicone bronchial plug was placed to the target pulmonary segment in the treatment B group. The leak position was detected by biliary lithotomy balloon. Main outcome measures: duration of continuous leakage. Secondary end-points included the lung reexpanded, hospital costs and hospital stays etc.
Sponsor: Tang-Du Hospital

Current Primary Outcome: Duration of air leakage [ Time Frame: up to two weeks ]

Original Primary Outcome: Same as current

Current Secondary Outcome: duration of pulmonary atelectasis [ Time Frame: up to two weeks ]

Original Secondary Outcome: Same as current

Information By: Tang-Du Hospital

Dates:
Date Received: November 18, 2014
Date Started: February 2015
Date Completion: June 2017
Last Updated: January 4, 2016
Last Verified: January 2016