Clinical Trial: Adrenal Functions in Autosomal Dominant Polycystic Kidney Disease

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Assessment of Adrenal Functions in Patients With Autosomal Dominant Polycystic Kidney Disease

Brief Summary: We aimed to evaluate the hypothalamus-pituitary-adrenal axis in autosomal dominant polycystic kidney disease (ADPKD) patients. Twenty two ADPKD patients and 27 healthy subjects were enrolled.

Detailed Summary:

CONTEXT: Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease and extrarenal manifestations may be observed in many organ systems. Hypothalamus-pituitary-adrenal axis in patients with ADPKD was not evaluated extensively.

OBJECTIVE: We aimed to evaluate the hypothalamus-pituitary-adrenal axis in ADPKD patients.

METHODS: Twenty two ADPKD patients and 27 healthy subjects were enrolled. Basal dehydroepiandrosterone-sulfate (DHEAS) levels and cortisol and dehydroepiandrosterone responses to low dose short adrenocorticotropin stimulation test were assessed. Correlation analyses of these parameters with glomerular filtration rates, renal volumes and pain characteristics in patients with ADPKD were done.

Sponsor: Istanbul University

Current Primary Outcome: Inadequate response to tetracosactin infusion [ Time Frame: 30 and 60 minutes after the drug is administered ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Istanbul University

Dates:
Date Received: December 31, 2007
Date Started: September 2006
Date Completion:
Last Updated: February 17, 2009
Last Verified: February 2008