Clinical Trial: The Effect of High and Low Sodium Intake on Urinary Aquaporin-2 in Autosomal Dominant Polycystic Kidney Disease
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: The Effect of High and Low Sodium Intake on Urinary Aquaporin-2 in Autosomal Dominant Polycystic Kidney Disease, During Basal Conditions and After Hypertonic Saline Infusi
Brief Summary:
The aim of the study is to test the following hypotheses:
- that the function and/or regulation of AQP2 and /or ENaC in the principal cells is abnormal in autosomal dominant polycystic kidney disease.
- if an abnormal function of the principal cells is present in autosomal dominant polycystic kidney disease, this woll become more pronounced at high and low sodium intake.
Detailed Summary:
Sponsor: Regional Hospital Holstebro
Current Primary Outcome: u-AQP-2; fractional sodium excretion, p-vasopressin; p-aldosterone. [ Time Frame: Before and after hypertonic saline infusion after 4 days on high and low sodium diet, respectively. ]
Original Primary Outcome: u-AQP-2; fractional sodium excretion, p-vasopressin; p-aldosterone.
Current Secondary Outcome: u-p-AQP-2; u-ENaC (alpha, beta, gamma); CH2O; u-cAMP; uPGE-2, GFR. [ Time Frame: Before and after hypertonic saline infusion after 4 days on high and low sodium diet, respectively. ]
Original Secondary Outcome: u-p-AQP-2; u-ENaC (alpha, beta, gamma); CH2O; u-cAMP; uPGE-2, GFR.
Information By: Regional Hospital Holstebro
Dates:
Date Received: December 10, 2006
Date Started: October 2006
Date Completion:
Last Updated: December 4, 2011
Last Verified: December 2011
