Clinical Trial: Use of Copeptin in Diabetes Insipidus

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title: Use of Copeptin in the Differential Diagnosis of Diabetes insipidus-a Prospective International Study

Brief Summary: Prospective evaluation of the novel biomarker copeptin in the differential diagnosis of diabetes insipidus against the standard diagnostic test methods.

Detailed Summary:

Purpose of this study is to compare the overall diagnostic accuracy of the three following diagnostic test procedures in diabetes insipidus (central, nephrogen) and primary polydipsia: a) classical water deprivation test alone, b) classical water deprivation test plus plasma copeptin cut-off levels, c) hypertonic saline infusion test plus plasma copeptin measurement.

The investigators hypothesize that firstly b) and c) is better as a). Secondly the investigators hypothesize that c) is non-inferior to b).

Sponsor: University Hospital, Basel, Switzerland

Current Primary Outcome: Discriminative value of copeptin during different diagnostic tests. [ Time Frame: beginning and end of protocol, up to 8hours ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: University Hospital, Basel, Switzerland

Dates:
Date Received: September 9, 2013
Date Started: January 2015
Date Completion: December 2018
Last Updated: January 9, 2017
Last Verified: January 2017